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ea0099rc3.3 | Rapid Communications 3: Adrenal and Cardiovascular Endocrinology | Part I | ECE2024

Quantifying variability in ambulatory 24-hour tissue hormones for personalised management of hormonal replacement in patients with adrenal insufficiency

Botusan Ileana R. , Berinder Katarina , Methlie Paal , Upton Thomas , Zavala Eder , Russell Georgina , Simunkova Katerina , Vassiliadi Dimitra , Marinelli Isabella , Grytaas Marianne Aardal , Tsagarakis Stylianos , Lightman Stafford , Husebye Eystein Sverre , Kampe Olle , Oksnes Marianne , Bensing Sophie

Background: Recently, we have shown that ambulatory 24-hour dynamic steroid profiling using the newly developed U-RHYTHM system is possible and presented the circadian and ultradian rhythmicity of adrenal hormones in a healthy cohort. With U-RHYTHM, multiple hormones can be sampled simultaneously, and the free active hormones can be measured in local tissue where the effect is exerted. Thus the hormone fingerprint resulting from replacement therapy in individual patients can b...

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Quantifying variability in ambulatory 24-hour tissue hormones for personalised management of hormonal replacement in patients with adrenal insufficiency

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